In the last years, a significant advance in the field of respiratory stem cell biology has occurred. The field has acquired deeper knowledge about the identity, regulation and functions of lung epithelial stem cells during development, homeostasis, regeneration and disease. Even novel lung epithelial progenitor cells that develop after injury and that are necessary intermediates during regeneration have been identified.
Lung stem cell niches including supportive stromal cells as well as the extracellular matrix (compounds and biomechanics) where they are embedded in, are currently better defined. However, there is still little knowledge about the regulation of lung stem cell behaviour by the niche and further investigation is required. Understanding the interactions between lung stem cells and their niche as well as studying how changes in the local microenvironment affect stem cell behaviour, will contribute to comprehend the development of disease and to discover novel therapeutic approaches.
The discussions will include but not be limited to:
- Airway and Alveolar Stem cells in lung health and disease
- Novel epithelial progenitor cell populations
- Epithelial-mesenchymal interactions in lung development, regeneration and disease
- Embryonic lung stem cell niche in lung development
- Stem cell niches in lung homeostasis and repair
- Mechanical regulation of lung stem cells
Confirmed Keynote Speaker
Edward Morrisey (University of Pennsylvania)
Confirmed Invited Speakers
Brigitte Gomperts (University of California, Los Angeles)
DYNAMIC Wnt SECRETING NICHES REGULATE PROXIMAL AIRWAY EPITHELIAL REGENERATION AND AGING
Joo Hyeon-Lee (University of Cambridge)
Carla Kim (Boston Children's Hospital)
REGULATION OF LUNG PROGENITORS AND THEIR MICROENVIRONMENT
Parviz Minoo (University of Southern California and Children's Hospital)
MESENCHYMAL CONTROL OF EPITHELIAL AND ENDOTHELIAL PROGENITORS DURING ALVEOLOGENESIS
Shahin Rafii (Weill Cornell Medicine)
Jay Rajagopal (Massachusetts General Hospital)
AIRWAYS, INJURIES, AND REGENERATION: NEW CELLS AND NEW BEHAVIORS
Emma Rawlins (University of Cambridge)
EPITHELIAL - MESENCHYMAL INTERACTIONS CONTROLLING HUMAN LUNG DEVELOPMENT
Herbert Schiller (Helmholtz Zentrum München)
Barry Stripp (Cedars-Sinai Medical Center)
DYNAMIC REGULATION OF EPITHELIAL PROGENITOR CELL FATE BY INNATE IMMUNE ACTIVATION
Xin Sun (University of California, San Diego)
PULMONARY NEUROENDOCRINE CELLS IN LUNG FLUID CONTROL
Nan Tang (National Institute of Biological Sciences, Beijing)
ALVEOLAR REGENERATION, FORCE AND ENERGY
Purushothama Rao Tata (Duke University School of Medicine)
Please send poster abstract submissions via email to the Conference Manager, Jack. The poster deadline is noted above. We advise early submission to avoid disappointment due to limited slots.
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Lab Package Registration Fee: £500
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Unfortunately all grants have now been awarded.