We have reached a fascinating point in our research on the ubiquitin system’s function, physiology and roles in disease. The attachment of ubiquitin to a protein in the cytosol was first identified as a means to enable degradation of proteins in the cytosol by the proteasome. It was much later that it was discovered that the ubiquitin system fulfils another crucial cellular function: through the dynamics offered by ubiquitination and subsequent deubiquitination it gives a multitude of signalling pathways the required plasticity to initiate but also to limit their signalling output in an exquisitely controlled manner. Whereas certain signalling-related functions employ ubiquitin’s proteasome-targeting function, e.g. the activation of NF-kB following degradation of I-kB, most signalling-related functions of the ubiquitin system are mediated by different types of ubiquitin chains acting as scaffolds for the recruitment of signalling modules to protein complexes which serve as platforms for the triggering of specific signalling complexes.
Rather than discussing mainly structural aspects of the ubiquitin system, this virtual conference is dedicated to the study of functional roles of the ubiquitin system, how it works to ensure normal signal transduction, what are the pathological consequences when it is perturbed and how can we harness our knowledge of the ubiquitin system therapeutically for more efficacious treatment of diseases with high unmet clinical need, including cancer, chronic inflammatory and autoimmune disorders as well as neurodegenerative diseases.
Importantly, this virtual conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues that emerge from the study of the ubiquitin system will be presented and discussed.
Confirmed Plenary Speakers
Eric Baehrecke (UMass Medical School)
A NOVEL RELATIONSHIP BETWEEN UBIQUITIN, MITOCHONDRIA AND AUTOPHAGY
Ivan Dikic (Goethe University Frankfurt)
UBIQUITIN SYSTEM IN BACTERIAL INFECTIONS
Rachel Klevit (University of Washington)
BRCA1/BARD1, TWENTY YEARS LATER
Pascal Meier (ICR London)
UBIQUITIN-MEDIATED REGULATION OF NECROPTOSIS
Michele Pagano (NYU)
UNCOVERING THE POWER OF PROTEIN DEGRADATION: MECHANISMS TO THERAPEUTIC STRATEGIES
Simona Polo (IFOM)
RIBONUCLEOPROTEIN GRANULES IN NEURONS AND OVARIES: DYNAMIC SENSORS MODULATED BY UBIQUITIN
John Silke (The Walter and Eliza Hall Institute of Medical Research)
UBIQUITIN AND DEAD BODIES, A DEGRADING BUSINESS
Sylvie Urbe (University of Liverpool)
DEUBIQUITINASES (DUBS): DRUGGABLE REGULATORS OF PROTEIN AND ORGANELLE HOMEOSTASIS
Confirmed Invited Speakers
Tim Clausen (IMP)
THERE IS A MEG IN UBIQUITIN WATERS
Brian Ferguson (University of Cambridge)
ANTI-VIRAL FUNCTIONS OF LINEAR UBIQUITIN CHAINS
Thorsten Hoppe (CECAD)
ORGANISMAL REGULATION OF UBIQUITIN-MEDIATED QUALITY CONTROL
Kim Newton (Genentech)
REGULATION OF CELL DEATH AND INFLAMMATION BY DUBs OTULIN AND CYLD
Michal Sharon (Weizmann Institute of Science)
SPECIFIC REGULATION OF THE 20S PROTEASOME COMPLEX
Domagoj Vucic (Genentech)
UBIQUITINATION REGULATES INFLAMMATORY SIGNALING BY RIP KINASES
Please send oral and poster abstract submissions via email to the Conference Manager, Laura. The oral and poster deadlines are noted above. We advise early submission to avoid disappointment due to limited slots.
We have complimentary registrations available for postdocs and students. Please submit an abstract for oral or poster consideration via email to Laura, along with a short message outlining why you would benefit from attending this conference. Applications must be submitted by 08th September 2021 for consideration.
A message from our Chairs…
'The field of ubiquitin biology and applications to clinical medicine is one of the most exciting topics in Biomedicine. With the realization that widely prescribed powerful immunomodulatory drugs (IMIDs) including thalidomide and its analogues lenalidomide and pomalidomide work by engaging ubiquitin mediated degradation of critical targets, the field has exploded. A PROTAC strategy (Proteolysis targeting chimera) is now underway at all major Biopharma enterprises to extend the lessons from the IMID field to specifically target unwanted proteins. The impact of the field is far reaching. Indeed, the Nobel Prize last year was given to researchers who worked out how hypoxia engages the ubiquitin system to regulate oxygen availability. The future for the field has never been brighter. Clear your calendars and come join what should be a most exciting virtual conference. It will focus on the myriad ways ubiquitin controls the signaling circuitry of life. If the regulation exerted by ubiquitin goes awry the consequences are devastating: it promulgates the pathology associated with inflammatory disease states, cancer and neurodegeneration.'
We offer two price options for our virtual conferences. Please see below for details. If you register for a conference via our website, credit card payment is required. If you would prefer to pay via bank transfer, please contact us for an alternative registration method.
Standard Registration Fee: £225
This price grants access to the virtual conference for one user. Please note, your account is designed for single use. If another user tries to log into your account to access the virtual conference at the same time, the original user will be logged out immediately.
Lab Package Registration Fee: £520
This price grants access to the virtual conference for three users from the same lab. Please contact us if you are interested in this package for further details.
We have complimentary registrations available for postdocs and students. Please submit an abstract for oral or poster consideration via email to Laura, along with a short message outlining why you would benefit from attending this conference. Applications must be submitted by 8th September 2021 for consideration.
Please note refunds can only be issued within 14 days of booking. Outside of this, all registration fees are non-refundable. Please see our Terms and Conditions for further details.